Identification of novel drug targets for osteoarthritis by integrating genetics and proteomes from blood.

ABSTRACT:

Background

Osteoarthritis (OA) is a degenerative osteoarticular disease, involving genetic predisposition. How the risk variants confer the risk of OA through their effects on proteins remains largely unknown. Therefore, we aimed to discover new and effective drug targets for OA and its subtypes.

Methods

A proteome-wide association study (PWAS) was performed based on OA and its subtypes genome-wide association studies (GWAS) summary datasets and the protein quantitative trait loci (pQTL) data. Subsequently, Mendelian randomization (MR) and colocalization analysis was conducted to estimate the associations between protein and OA risk. The replication analysis was performed in an independent dataset of human plasma pQTL data.

Results

The abundance of seven proteins was

SUBMITTER: Song S 

PROVIDER: S-EPMC11389225 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature