Trajectories of peripheral white blood cells count around the menopause: a prospective cohort study.

ABSTRACT:

Background

Menopause significantly impacts the immune system. Postmenopausal women are more susceptible to infection. Nonetheless, the pattern of change in peripheral white blood cell counts around the menopause remains poorly understood.

Methods

We conducted a prospective longitudinal cohort study with repeated measurements using Kailuan cohort study of 3632 Chinese women who participated in the first checkup (2006-2007) and reached their final menstrual period (FMP) by the end of the seventh checkup (2018-2020). Peripheral WBC count indicators included total white blood cells (TWBC), neutrophils (NEUT), lymphocytes (LYM), and monocytes (MON). Multivariable mixed effects regressions fitted piece-wise linear models to repeated measures of WBC count indicators as a function o

SUBMITTER: Dai Q 

PROVIDER: S-EPMC11389272 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature