Effects of glycaemic control on memory performance, hippocampal volumes and depressive symptomology.

ABSTRACT:

Background

Diabetes and poor glycaemic control have been shown to negatively impact cognitive abilities, while also raising risk of both mood disorders and brain structural atrophy. Sites of atrophy include the hippocampus, which has been implicated in both memory performance and depression. The current study set out to better characterise the associations between poor glycaemic control, memory performance, and depression symptoms, and investigate whether loss of hippocampal volume could represent a neuropathological mechanism underlying these.

Methods

1331 participants (60.9% female, age range 18-88 (Mean = 44.02), 6.5% with likely diabetes) provided HbA1c data (as an index of glycaemic control), completed a word list learning task, and a validated depression scale. A subsa

SUBMITTER: Yatagan Sevim G 

PROVIDER: S-EPMC11389280 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature