PNBACE: an ensemble algorithm to predict the effects of mutations on protein-nucleic acid binding affinity.

ABSTRACT:

Background

Mutations occurring in nucleic acids or proteins may affect the binding affinities of protein-nucleic acid interactions. Although many efforts have been devoted to the impact of protein mutations, few computational studies have addressed the effect of nucleic acid mutations and explored whether the identical methodology could be applied to the prediction of binding affinity changes caused by these two mutation types.

Results

Here, we developed a generalized algorithm named PNBACE for both DNA and protein mutations. We first demonstrated that DNA mutations could induce varying degrees of changes in binding affinity from multiple perspectives. We then designed a group of energy-based topological features based on different energy networks, which were combined with o

SUBMITTER: Xiao SR 

PROVIDER: S-EPMC11389284 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature