Sarcopenia as a predictor of nutritional status and comorbidities: a cross-sectional and mendelian randomization study.

ABSTRACT:

Background

With the advancement of world population aging, age-related sarcopenia (SP) imposes enormous clinical burden on hospital. Clinical research of SP in non-geriatric wards has not been appreciated, necessitating further investigation. However, observational studies are susceptible to confounders. Mendelian randomization (MR) can effectively mitigate bias to assess causality.

Objective

To investigate the correlation between SP and comorbidities in orthopedic wards, and subsequently infer the causality, providing a theoretical basis for developing strategies in SP prevention and treatment.

Methods

Logistic regression models were employed to assess the correlation between SP and comorbidities. The MR analysis was mainly conducted with inverse variance weighted, u

SUBMITTER: Liu C 

PROVIDER: S-EPMC11389292 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature