Early inhibition of BRD4 facilitates iPSC reprogramming via accelerating rDNA dynamic expression.

ABSTRACT:

Background

iPSC reprogramming technology exhibits significant promise in the realms of clinical therapeutics, disease modeling, pharmaceutical drug discovery, and various other applications. However, the extensive utilization of this technology has encountered impediments in the form of inefficiency, prolonged procedures, and ambiguous biological processes. Consequently, in order to improve this technology, it is of great significance to delve into the underlying mechanisms involved in iPSC reprogramming. The BET protein BRD4 plays a crucial role in the late stage of reprogramming; however, its precise function in the early stage remains unclear.

Results

Our study aims to investigate BRD4's role in the early stages of iPSC reprogramming. Our investigation reveals that early

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11389306 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature