Urine-derived stem cells serve as a robust platform for generating native or engineered extracellular vesicles.

ABSTRACT:

Background

Mesenchymal stromal cell (MSC) therapy holds great potential yet efficacy and safety concerns with cell therapy persist. The beneficial effects of MSCs are often attributed to their secretome that includes extracellular vesicles (EVs). EVs carry biologically active molecules, protected by a lipid bilayer. However, several barriers hinder large-scale MSC EV production. A serum-free culturing approach is preferred for producing clinical-grade MSC-derived EVs but this can affect both yield and purity. Consequently, new strategies have been explored, including genetically engineering MSCs to alter EV compositions to enhance potency, increase circulation time or mediate targeting. However, efficient transfection of MSCs is challenging. Typical sources of MSC include adipose t

SUBMITTER: Boysen AT 

PROVIDER: S-EPMC11389316 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature