Coupled pulsatile vascular and paravascular fluid dynamics in the human brain.

ABSTRACT:

Background

Cardiac pulsation propels blood through the cerebrovascular network to maintain cerebral homeostasis. The cerebrovascular network is uniquely surrounded by paravascular cerebrospinal fluid (pCSF), which plays a crucial role in waste removal, and its flow is suspected to be driven by arterial pulsations. Despite its importance, the relationship between vascular and paravascular fluid dynamics throughout the cardiac cycle remains poorly understood in humans.

Methods

In this study, we developed a non-invasive neuroimaging approach to investigate the coupling between pulsatile vascular and pCSF dynamics within the subarachnoid space of the human brain. Resting-state functional MRI (fMRI) and dynamic diffusion-weighted imaging (dynDWI) were retrospectively cardiac-alig

SUBMITTER: Wright AM 

PROVIDER: S-EPMC11389319 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature