The SaeRS two-component system regulates virulence gene expression in group B Streptococcus during invasive infection.

ABSTRACT: Group B Streptococcus (GBS) is a pathobiont responsible for invasive infections in neonates and the elderly. The transition from a commensal to an invasive pathogen relies on the timely regulation of virulence factors. In this study, we characterized the role of the SaeRS two-component system in GBS pathogenesis. Loss-of-function mutations in the SaeR response regulator decrease virulence in mouse models of invasive infection by hindering the ability of bacteria to persist at the inoculation site and to spread to distant organs. Transcriptome and in vivo analysis reveal a specialized regulatory system specifically activated during infection to control the expression of only two virulence factors: the PbsP adhesin and the BvaP secreted protein. The in vivo surge in SaeR

SUBMITTER: Coppolino F 

PROVIDER: S-EPMC11389388 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature