Proteome-wide Mendelian randomization identified potential drug targets for migraine.

ABSTRACT:

Background

Migraine is a highly prevalent and complex neurovascular disease. However, the currently available therapeutic drugs often fall to adequately meet clinical needs due to limited effectiveness and numerous undesirable side effects. This study aims to identify putative novel targets for migraine treatment through proteome-wide Mendelian randomization (MR).

Methods

We utilized MR to estimate the causal effects of plasma proteins on migraine and its two subtypes, migraine with aura (MA) and without aura (MO). This analysis integrated plasma protein quantitative trait loci (pQTL) data with genome-wide association studies (GWAS) findings for these migraine phenotypes. Moreover, we conducted a phenome-wide MR assessment, enrichment analysis, protein-protein interaction ne

SUBMITTER: Xiong Z 

PROVIDER: S-EPMC11389401 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature