The L-lactate dehydrogenases of <i>Pseudomonas aeruginosa</i> are conditionally regulated but both contribute to survival during macrophage infection.

ABSTRACT: Pseudomonas aeruginosa is an opportunistic pathogen that thrives in environments associated with human activity, including soil and water altered by agriculture or pollution. Because L-lactate is a significant product of plant and animal metabolism, it can serve as a carbon source for P. aeruginosa in the diverse settings that it inhabits. In this study, we evaluate the production and use of two redundant P. aeruginosa L-lactate dehydrogenases, termed LldD and LldA. We confirm that the protein LldR represses lldD and identify a new transcription factor, called LldS, that activates lldA; these distinct regulators and the genomic contexts of lldD and lldA contribute to their differential expression. We demonstrate that the lldD and l

SUBMITTER: Florek LC 

PROVIDER: S-EPMC11389411 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature