Pseudomonas aeruginosa surface motility and invasion into competing communities enhance interspecies antagonism.

ABSTRACT: Chronic polymicrobial infections involving Pseudomonas aeruginosa and Staphylococcus aureus are prevalent, difficult to eradicate, and associated with poor health outcomes. Therefore, understanding interactions between these pathogens is important to inform improved treatment development. We previously demonstrated that P. aeruginosa is attracted to S. aureus using type IV pili (TFP)-mediated chemotaxis, but the impact of attraction on S. aureus growth and physiology remained unknown. Using live single-cell confocal imaging to visualize microcolony structure, spatial organization, and survival of S. aureus during coculture, we found that interspecies chemotaxis provides P. aeruginosa a competitive advantage by promoting invasion into and dis

SUBMITTER: Sanchez-Pena A 

PROVIDER: S-EPMC11389416 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature