Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort.

ABSTRACT:

Background

Gestational age (GEAA) estimated by newborn DNA methylation (GAmAge) is associated with maternal prenatal exposures and immediate birth outcomes. However, the association of GAmAge with long-term overweight or obesity (OWO) trajectories is yet to be determined.

Methods

GAmAge was calculated for 831 children from a US predominantly urban, low-income, multi-ethnic birth cohort based on cord blood DNA methylation profile using Illumina EPIC array. Repeated anthropometric measurements aligned with pediatric primary care schedule allowed us to calculate body-mass-index percentiles (BMIPCT) at specific age and to define long-term weight trajectories from birth to 18 years.

Results

GAmAge was associated with BMIPCT trajectories, defined by 4 groups: stable (consis

SUBMITTER: Yaskolka Meir A 

PROVIDER: S-EPMC11389437 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature