Fgf9 promotes incisor dental epithelial stem cell survival and enamel formation.

ABSTRACT:

Background

Understanding the role of cytokines in tooth development is critical for advancing dental tissue engineering. Fibroblast growth factor 9 (FGF9) is the only FGF consistently expressed throughout dental epithelial tissue, from the initiation of tooth bud formation to tooth maturation. However, mice lacking Fgf9 (Fgf9^-/-) surprisingly show no obvious abnormalities in tooth development, suggesting potential compensation by other FGFs. Here we report findings from an Fgf9^S99N mutation mouse model, a loss-of-function mutation with a dominant negative effect. Our study reveals that Fgf9 is crucial for dental epithelial stem cell (DESC) survival and enamel formation.

Methods

To dissect the role of Fgf9 in tooth development, we performed the micro-CT,

SUBMITTER: Tang L 

PROVIDER: S-EPMC11389439 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature