Maternal Exposure to Per- and Polyfluoroalkyl Substances and Offspring Chromosomal Abnormalities: The Japan Environment and Children's Study.

ABSTRACT:

Background

Although recent in vitro experimental results have raised the question of whether maternal exposure to per- and polyfluoroalkyl substances (PFAS) may be a potential environmental risk factor for chromosomal abnormalities, epidemiological studies investigating these associations are lacking.

Objectives

This study examined whether prenatal PFAS exposure is associated with a higher prevalence of chromosomal abnormalities among offspring.

Methods

We used data from the Japan Environment and Children's Study, a nationwide birth cohort study, and employed logistic regression models to examine the associations between maternal plasma PFAS concentrations in the first trimester and the diagnosis of chromosomal abnormalities in all births (artificial abortions,

SUBMITTER: Hasegawa K 

PROVIDER: S-EPMC11389478 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature