The mrp-3 gene is involved in haem efflux and detoxification in a blood-feeding nematode.

ABSTRACT:

Background

Haem is essential but toxic for metazoan organisms. Auxotrophic nematodes can acquire sufficient haem from the environment or their hosts in the meanwhile eliminate or detoxify excessive haem through tightly controlled machinery. In previous work, we reported a role of the unique transporter protein HRG-1 in the haem acquisition and homeostasis of parasitic nematodes. However, little is known about the haem efflux and detoxification via ABC transporters, particularly the multiple drug resistance proteins (MRPs).

Results

Here, we further elucidate that a member of the mrp family (mrp-3) is involved in haem efflux and detoxification in a blood-feeding model gastrointestinal parasite, Haemonchus contortus. This gene is haem-responsive and dominantly expressed in the

SUBMITTER: Tong D 

PROVIDER: S-EPMC11389519 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature