In vitro study on efficacy of SKF7^®, a Malaysian medicinal plant product against SARS-CoV-2.

ABSTRACT:

Background

In early 2020, COVID-19 pandemic has mobilized researchers in finding new remedies including repurposing of medicinal plant products focusing on direct-acting antiviral and host-directed therapies. In this study, we performed an in vitro investigation on the standardized Marantodes pumilum extract (SKF7^®) focusing on anti-SARS-CoV-2 and anti-inflammatory activities.

Methods

Anti-SARS-CoV-2 potential of the SKF7^® was evaluated in SARS-CoV-2-infected Vero E6 cells and SARS-CoV-2-infected A549 cells by cytopathic effect-based assay and RT-qPCR, respectively. Target based assays were performed on the SKF7^® against the S1-ACE2 interaction and 3CL protease activities. Anti-inflammatory activity of the SKF7^® was evaluated by ni

SUBMITTER: Mohd Abd Razak MR 

PROVIDER: S-EPMC11389526 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature