Renal protective and immunoregulatory effects of Lactobacillus casei strain Shirota in nephropathy-prone mice.

ABSTRACT:

Introduction

The incidence of severe acute kidney injury (AKI) is considerably high worldwide. A previous study showed that gut microbial dysbiosis was a hallmark of AKI in mice. Whether the probiotic Lactobacillus casei strain Shirota (LcS) plays a role in kidney disease, particularly AKI, remains unclear.

Methods

To investigate the effects of LcS on kidney injury, tubule-specific conditional von Hippel-Lindau gene-knockout C57BL/6 mice (Vhlh^del/del mice) were supplemented without (Ctrl) or with probiotics (LcS) in Experiment 1, and their lifespan was monitored. Additionally, the Vhlh^del/+ mice were supplemented without (Ctrl and AA) or with probiotics (LcS and LcS + AA) in Experiment 2. Probiotic LcS (1 × 10⁹ colony-for

SUBMITTER: Chan CW 

PROVIDER: S-EPMC11389617 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature