Identification and verification of disulfidptosis-related genes in sepsis-induced acute lung injury.

ABSTRACT:

Background

Sepsis-induced acute lung injury (ALI) is a common and serious complication of sepsis that eventually progresses to life-threatening hypoxemia. Disulfidptosis is a newly discovered type of cell death associated with the pathogenesis of different diseases. This study investigated the potential association between sepsis-induced acute lung injury and disulfidptosis by bioinformatics analysis.

Methods

In order to identify differentially expressed genes (DEGs) linked to sepsis, we screened appropriate data sets from the GEO database and carried out differential analysis. The key genes shared by DEGs and 39 disulfidptosis-related genes were identified: ACSL4 and MYL6 mRNA levels of key genes were detected in different datasets. We then used a series of bioinformatics a

SUBMITTER: Zhang A 

PROVIDER: S-EPMC11389619 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature