First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort.

ABSTRACT:

Background

Hypertensive disorders of pregnancy (HDP) such as preeclampsia and gestational hypertension are major contributors to maternal and child morbidity and mortality. Previous studies have reported associations with selected metals and vitamins but are limited in sample size and non-prospective study designs. We evaluated prospective associations of metal mixtures with HDP and tested interactions by vitamins.

Study design

We measured first trimester (median = 10.1 weeks) concentrations of essential (copper, magnesium, manganese, selenium, zinc) and nonessential (arsenic, barium, cadmium, cesium, mercury, lead) metals in red blood cells (n = 1,386) and vitamins (B₁₂ and folate) in plasma (n = 924) in Project Viva, a pre-birth US cohort. We collected diagnosis

SUBMITTER: Hernandez-Castro I 

PROVIDER: S-EPMC11389723 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature