Simultaneous electromechanical monitoring in engineered heart tissues using a mesoscale framework.

ABSTRACT: Engineered heart tissues (EHTs) generated from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent powerful platforms for human cardiac research, especially in drug testing and disease modeling. Here, we report a flexible, three-dimensional electronic framework that enables real-time, spatiotemporal analysis of electrophysiologic and mechanical signals in EHTs under physiological loading conditions for dynamic, noninvasive, longer-term assessments. These electromechanically monitored EHTs support multisite measurements throughout the tissue under baseline conditions and in response to stimuli. Demonstrations include uses in tracking physiological responses to pharmacologically active agents and in capturing electrophysiological characteristics of reentrant arrh

SUBMITTER: Fullenkamp DE 

PROVIDER: S-EPMC11389789 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature