Clinical Phenotyping for Prognosis and Immunotherapy Guidance in Bacterial Sepsis and COVID-19.

ABSTRACT:

Objectives

It is suggested that sepsis may be classified into four clinical phenotypes, using an algorithm employing 29 admission parameters. We applied a simplified phenotyping algorithm among patients with bacterial sepsis and severe COVID-19 and assessed characteristics and outcomes of the derived phenotypes.

Design

Retrospective analysis of data from prospective clinical studies.

Setting

Greek ICUs and Internal Medicine departments.

Patients and interventions

We analyzed 1498 patients, 620 with bacterial sepsis and 878 with severe COVID-19. We implemented a six-parameter algorithm (creatinine, lactate, aspartate transaminase, bilirubin, C-reactive protein, and international normalized ratio) to classify patients with bacterial sepsis intro previously define

SUBMITTER: Karakike E 

PROVIDER: S-EPMC11390041 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature