Revealing a hidden conducting state by manipulating the intracellular domains in K_V10.1 exposes the coupling between two gating mechanisms.

ABSTRACT: The KCNH family of potassium channels serves relevant physiological functions in both excitable and non-excitable cells, reflected in the massive consequences of mutations or pharmacological manipulation of their function. This group of channels shares structural homology with other voltage-gated K⁺ channels, but the mechanisms of gating in this family show significant differences with respect to the canonical electromechanical coupling in these molecules. In particular, the large intracellular domains of KCNH channels play a crucial role in gating that is still only partly understood. Using KCNH1(K_V10.1) as a model, we have characterized the behavior of a series of modified channels that could not be explained by the current models. With electrop

SUBMITTER: Abdelaziz R 

PROVIDER: S-EPMC11390113 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature