Exploring the causal relationship between the immune cell-inflammatory factor axis and lung cancer: a Mendelian randomization study.

ABSTRACT:

Background

Lung cancer is a major health burden globally and smoking is a well-known risk factor. It has been observed that chronic inflammation contributes to lung cancer progression, with immune cells and inflammatory cytokines implicated in tumor development. Clarifying the causal links between these immune components and lung cancer could enhance prevention and therapy.

Methods

We performed Mendelian randomization (MR) to explore causal connections between immune cells, inflammatory markers, and lung cancer risk, using genetic variants as instruments. Data from GWAS on these variables underpinned our MR analyses.

Results

Our findings indicated an inverse association between some immune cells and lung cancer risk, implying that more immune cells might be protective

SUBMITTER: Zhu L 

PROVIDER: S-EPMC11390355 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature