Exploring causal correlations between plasma proteins and peripheral neuropathy: a Mendelian randomization.

ABSTRACT:

Background

Peripheral neuropathy (PN) is a common neurological disorder, and circulating plasma proteins with causal genetic evidence are a major source of therapeutic targets. This study identifies several potential plasma proteins that are causally related to PN risk, providing new insights into protein-mediated pathogenesis of PN and potential targets for novel therapies.

Methods

To identify potential therapeutic targets for PN, we employed two-sample Mendelian randomization (MR) to identify plasma proteins associated with six common PN. First, we screened for proteins related to PN using genome-wide association studies (GWAS), obtaining genetic data on plasma proteomes from 35,559 Icelanders. Summary data for six common PN, including Carpal Tunnel Syndrome (CTS), Trigemi

SUBMITTER: Song M 

PROVIDER: S-EPMC11390399 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature