Exploring the molecular and immune landscape of cellular senescence in lung adenocarcinoma.

ABSTRACT:

Introduction

The connection between aging and cancer is complex. Previous research has highlighted the association between the aging process of lung adenocarcinoma (LUAD) cells and the immune response, yet there remains a gap in confirming this through single-cell data validation. Here, we aim to develop a novel aging-related prognostic model for LUAD, and verify the alterations in the genome and immune microenvironment linked to cellular senescence.

Methods

We integrated a comprehensive collection of senescence genes from the GenAge and CellAge databases and employed the least absolute shrinkage and selection operator (LASSO) Cox analysis to construct and validate a novel prognostic model for LUAD. This model was then utilized to examine the relationship between aging, tumo

SUBMITTER: Ru K 

PROVIDER: S-EPMC11390420 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature