Celiac disease diagnosis: transglutaminase, duodenal biopsy and genetic tests correlations.

ABSTRACT:

Introduction

Celiac disease (CD) is an autoimmune enteropathy triggered by gluten ingestion in genetically susceptible individuals. The haplotypes HLA-DQ2 and DQ8, transglutaminase (TGA) antibodies, and biopsy findings are the main tests performed in the evaluation and CD diagnosis. The objective was to establish possible correlations between transglutaminase levels, genetic markers tests, and qualitative intestinal biopsy findings (modified Marsh classification) at the diagnosis.

Methods

A retrospective cohort study. The selection criteria were confirmed CD cases with genetic tests performed. Statistical analysis was done mainly through One-way ANOVA, Kendall's correlation coefficient (T), and linear regression.

Results

The study included 112 patients, with a mean ag

SUBMITTER: Schesquini-Roriz KRP 

PROVIDER: S-EPMC11390444 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature