Cooperative thalamocortical circuit mechanism for sensory prediction errors.

ABSTRACT: The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and the outcomes of our actions. Discrepancies between expected and actual events, referred to as prediction errors, are leveraged to update the internal model and guide our attention towards unexpected events^1-10. Despite the importance of prediction-error signals for various neural computations across the brain, surprisingly little is known about the neural circuit mechanisms responsible for their implementation. Here we describe a thalamocortical disinhibitory circuit that is required for generating sensory prediction-error signals in mouse primary visual cortex (V1). We show that violating animals' predictions by an unexpected visual stimulus preferentially boosts r

SUBMITTER: Furutachi S 

PROVIDER: S-EPMC11390482 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature