Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice.

ABSTRACT: Oscillations, a highly conserved brain function across mammalian species, play a pivotal role in both brain physiology and pathology. Traumatic brain injury (TBI) frequently results in subacute and chronic alterations in brain oscillations, which are often associated with complications like post-traumatic epilepsy (PTE) in patients and animal models. We recently conducted longitudinal recordings of local field potential from the contralateral hippocampus of 12 strains of recombinant inbred Collaborative Cross (CC) mice and classical laboratory inbred C57BL/6 J mice after lateral fluid percussion injury. In this study, we profiled the acute (<12 h post-injury) and subacute (12-48 h post-injury) hippocampal oscillatory responses to TBI and evaluated their predictive value for PTE. We found d

SUBMITTER: Shannon T 

PROVIDER: S-EPMC11390562 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature