Exploring the gut microbiome and immunological landscape in kidney cancer: a Mendelian randomization analysis.

ABSTRACT:

Introduction

Kidney cancer (KC) is a significant health burden globally, with over 400,000 new cases estimated in 2020. The prognosis of KC is influenced by various factors, including tumor spread, pathological characteristics, and molecular genetic changes. Recent studies have emphasized the involvement of gut microbiota and the immune system's contribution in the onset of KC. This extensive research endeavor sought to investigate the potential associations between diverse immune cell phenotypes, specific gut microbiota species, and their impact on the risk of developing KC, alongside the examination of circulating inflammatory proteins.

Methods

Adhering to the STROBE-MR guidelines, our investigation involved a two-stage Mendelian randomization (2SMR) analysis grounded on t

SUBMITTER: Lv S 

PROVIDER: S-EPMC11390574 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature