Free circulating versus extracellular vesicle-associated microRNA expression in canine T-cell lymphoma.

ABSTRACT:

Introduction

Canine lymphoma (cL) is one of the most frequent cancers in dogs. The T-cell lymphoma (TcL) is not the most common phenotype but presents an aggressive behavior. MicroRNAs (miRNAs), are small, single-stranded, non-coding RNA molecules which can circulate freely in blood or be associated with extracellular vesicles (EVs). The dysregulation of certain miRNAs has been identified in numerous types of human cancers and they have been largely investigated as possible tumors biomarkers in human medicine, while research in veterinary oncology is still scarce. The aim of this study was to compare the expression patterns of free circulating and EV-associated miRNAs in dogs with T-cell lymhoma (TcL) and healthy dogs.

Methods

Eight dogs with TcL were selected as the lymphom

SUBMITTER: Capuano C 

PROVIDER: S-EPMC11390581 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature