Association of metabolites on ischemic stroke subtypes: a 2-sample Mendelian randomization study.

ABSTRACT:

Background

Metabolomics is increasingly being utilized in IS research to elucidate the intricate metabolic alterations that occur during ischemic stroke (IS). However, establishing causality in these associations remains unclear between metabolites and IS subtypes. In this study, we employ Mendelian randomization (MR) to identify specific metabolites and investigate potential causal relationships between metabolites and IS subtypes.

Methods

MR analysis was conducted using genome-wide association study (GWAS) summary data. We obtained 1,091 blood metabolites and 309 metabolite ratios from the GWAS Catalog (GCST90199621-90201020), which gene sequencing data from 8,299 individuals from the Canadian Longitudinal Study. We obtained GWAS summary statistics for IS subtypes which in

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11390583 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature