Genes associated with fitness and disease severity in the pan-genome of mastitis-associated <i>Escherichia coli</i>.

ABSTRACT:

Introduction

Bovine mastitis caused by Escherichia coli compromises animal health and inflicts substantial product losses in dairy farming. It may manifest as subclinical through severe acute disease and can be transient or persistent in nature. Little is known about bacterial factors that impact clinical outcomes or allow some strains to outcompete others in the mammary gland (MG) environment. Mastitis-associated E. coli (MAEC) may have distinctive characteristics which may contribute to the varied nature of the disease. Given their high levels of intraspecies genetic variability, virulence factors of commonly used MAEC model strains may not be relevant to all members of this group.

Methods

In this study, we sequenced the genomes of 96 MAEC strains isolated fr

SUBMITTER: Olson MA 

PROVIDER: S-EPMC11390585 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature