Exploration of the ubiquitination-related molecular classification and signature to predict the survival and immune microenvironment in colon cancer.

ABSTRACT:

Background

Ubiquitination, a major post-translational modification, significantly impacts tumorigenesis, progression, and prognosis. This study aims to classify colon cancer at the molecular level and create a reliable signature using ubiquitination-related genes (URGs) to assess the immune microenvironment and prognosis.

Methods

We employed non-negative matrix factorization to subtype colon cancer based on ubiquitination-related gene (URG) expression patterns. Quantitative scores for 28 immune cell infiltrates and the tumor microenvironment were computed using single-sample gene set enrichment analysis (ssGSEA) and the Estimate algorithm. Subtype feature genes were selected through Lasso logistic regression and SVM-RFE algorithm. The ubiquitination-related signature was con

SUBMITTER: Xu JZ 

PROVIDER: S-EPMC11390591 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature