Repurposing antihypertensive drugs for pain disorders: a drug-target mendelian randomization study.

ABSTRACT:

Objective

Addressing the rising prevalence of pain disorders and limitations of current analgesics, our study explores repurposing antihypertensive drugs for pain management, inspired by the link between hypertension and pain. We leverage a drug-target Mendelian Randomization (MR) approach to explore their dual benefits and establish causal connections.

Methods

A comprehensive compilation of antihypertensive drug classes was undertaken through British National Formulary, with their target genes identified using the DrugBank database. Relevant single nucleotide polymorphisms (SNPs) associated with these targets were selected from published genomic studies on systolic blood pressure (SBP) as genetic instruments. These SNPs were validated through MR against acute coronary arter

SUBMITTER: Du K 

PROVIDER: S-EPMC11390634 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature