Enteric glial cell diversification is influenced by spatiotemporal factors and source of neural progenitors in mice.

ABSTRACT: Previously focused primarily on enteric neurons, studies of the enteric nervous system (ENS) in both health and disease are now broadening to recognize the equally significant role played by enteric glial cells (EGCs). Commensurate to the vast array of gastrointestinal functions they influence, EGCs exhibit considerable diversity in terms of location, morphology, molecular profiles, and functional attributes. However, the mechanisms underlying this diversification of EGCs remain largely unexplored. To begin unraveling the mechanistic complexities of EGC diversity, the current study aimed to examine its spatiotemporal aspects in greater detail, and to assess whether the various sources of enteric neural progenitors contribute differentially to this diversity. Based on established topo-morph

SUBMITTER: Lefevre MA 

PROVIDER: S-EPMC11390640 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature