Delivery mode and maternal gestational diabetes are important factors in shaping the neonatal initial gut microbiota.

ABSTRACT:

Background

The infant gut microbiome's establishment is pivotal for health and immune development. Understanding it unveils insights into growth, development, and maternal microbial interactions. Research often emphasizes gut bacteria, neglecting the phageome.

Methods

To investigate the influence of geographic or maternal factors (mode of delivery, mode of breastfeeding, gestational diabetes mellitus) on the gut microbiota and phages of newborns, we collected fecal samples from 34 pairs of mothers and their infants within 24 hours of delivery from three regions (9 pairs from Enshi, 7 pairs from Hohhot, and 18 pairs from Hulunbuir) using sterile containers. Gut microbiota analysis by Shotgun sequencing was subsequently performed.

Results

Our results showed that geograp

SUBMITTER: Shi X 

PROVIDER: S-EPMC11390658 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature