Investigating the therapeutic potential of hesperidin targeting CRISP2 in intervertebral disc degeneration and cancer risk mitigation.

ABSTRACT:

Background

Intervertebral disc degeneration (IDD) can lead to disc herniation and spinal instability, sometimes requiring surgical intervention. Currently, estrogen has a potential protective effect on IDD, and estrogen is associated with an increased risk of some cancers, such as breast and endometrial cancer. Therefore, it is important to identify natural compounds that estrogen analogues treat IDD while reducing the risk of tumor development.

Objective

This study aims to explore a natural metabolic treatment strategy by targeting CRISP2 with the natural compound Hesperidin to mimic the protective effects of estrogen on IDD and reduce the risk of tumor development.

Methods

Microarray data from healthy volunteers and IDD patients were extracted from the Gene Expressi

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11390660 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature