Application of DNA aptamers to block enterotoxigenic Escherichia coli toxicity in a Galleria mellonella larval model.

ABSTRACT: Enterotoxigenic Escherichia coli (ETEC) is the major bacterial cause of diarrheal diseases in pigs, particularly at young ages, resulting in significant costs to swine farming. The pathogenicity of ETEC is largely dependent on the presence of fimbriae and the ability to produce toxins. Fimbriae are responsible for their initial adhesion to the intestinal epithelial cells, leading to the onset of infection. In particular, the F4 type (K88) fimbriae are often attributed to neonatal infections and have also been associated with post-weaning diarrheal infections. This disease is traditionally prevented or treated with antibiotics, but their use is being severely restricted due to the emergence of resistant bacteria and their impact on human health. Emerging approaches such as aptamers t

SUBMITTER: Barros MM 

PROVIDER: S-EPMC11390681 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature