The association between physical activity and delayed neurocognitive recovery in elderly patients: a mediation analysis of pro-inflammatory cytokines.

ABSTRACT:

Background

Delayed neurocognitive recovery (dNCR) can result in unfavorable outcomes in elderly surgical patients. Physical activity (PA) has been shown to improve cognitive function, potentially by reducing systemic inflammatory responses. However, there is a lack of supportive data indicating whether PA has a protective effect against dNCR.

Aims

To examine the correlation between dNCR and PA, and to further analyze if pro-inflammatory cytokines mediate this relationship.

Methods

This study is a prospective nested case-control investigation of elderly patients who had knee replacement surgery. dNCR was defined as a decline in cognitive function compared with baseline by using a battery of neuropsychological tests. PA was assessed with the Physical Activity Scale for

SUBMITTER: Niu J 

PROVIDER: S-EPMC11390811 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature