Relationship between reasons for intermittent missing patient-reported outcomes data and missing data mechanisms.

ABSTRACT:

Purpose

Non-response (NR) to patient-reported outcome (PRO) questionnaires may cause bias if not handled appropriately. Collecting reasons for NR is recommended, but how reasons for NR are related to missing data mechanisms remains unexplored. We aimed to explore this relationship for intermittent NRs.

Methods

Patients with multiple myeloma completed validated PRO questionnaires at enrolment and 12 follow-up time-points. NR was defined as non-completion of a follow-up assessment within seven days, which triggered contact with the patient, recording the reason for missingness and an invitation to complete the questionnaire (denoted "salvage response"). Mean differences between salvage and previous on-time scores were estimated for groups defined by reasons for NR using linear

SUBMITTER: Nielsen LK 

PROVIDER: S-EPMC11390842 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature