Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.

ABSTRACT: Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles across four domains: the external exposome, proteome, metabolome and epigenetic age acceleration (EAA). For each domain, we assessed the similarity of co-twin profiles using Gaussian similarities in up to 257 young adult same-sex twin pairs (54% monozygotic). We additionally tested whether similarity in one domain translated into greater similarity in another. Results suggest that a lower degree of similarity in co-twins' exposome profiles was associated with greater differences in their behavior and

SUBMITTER: Drouard G 

PROVIDER: S-EPMC11390871 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature