Drug repurposing for Parkinson's disease by biological pathway based edge-weighted network proximity analysis.

ABSTRACT: Parkinson's disease is the second most frequent neurodegenerative disease, and its severity is increasing with extended life expectancy. Most of current treatments provide symptomatic relief; however, disease progression is not inhibited. There are multiple trials for treatments that target the causes of the disease but they were flawed. The mechanisms underlying neurodegenerative diseases are intricate, and understanding the interplay among the biological elements involved is crucial. These relationships can be effectively analyzed through biological networks, and the application of network-based analyses in the context of neurodegenerative disease treatment has gained considerable attention. Moreover, considering the significance differences in interactions between biological elements wi

SUBMITTER: Han M 

PROVIDER: S-EPMC11390918 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature