Single-cell sequencing revealed metabolic reprogramming and its transcription factor regulatory network in prostate cancer.

ABSTRACT:

Background/aims

Prostate cancer is the most frequently diagnosed cancer among men in the United States and is the second leading cause of cancer-related deaths in men. The incidence of prostate cancer is gradually rising due to factors such as aging demographics and changes in dietary habits. The objective of this study is to investigate the metabolic reprogramming changes occurring in prostate cancer and identify potential therapeutic targets.

Methods

In this study, we utilized single-cell sequencing to comprehensively characterize the alterations in metabolism and the regulatory role of transcription factors in various subtypes of prostate cancer.

Results

In comparison to benign prostate tissue, prostate cancer displayed substantial metabolic variations, notably exh

SUBMITTER: Wei G 

PROVIDER: S-EPMC11391037 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature