Novel imaging tools to study mitochondrial morphology in Caenorhabditis elegans.

ABSTRACT: Mitochondria exhibit a close interplay between their structure and function. Understanding this intricate relationship requires advanced imaging techniques that can capture the dynamic nature of mitochondria and their impact on cellular processes. However, much of the work on mitochondrial dynamics has been performed in single celled organisms or in vitro cell culture. Here, we introduce novel genetic tools for live imaging of mitochondrial morphology in the nematode Caenorhabditis elegans, addressing a pressing need for advanced techniques in studying organelle dynamics within live intact multicellular organisms. Through a comprehensive analysis, we directly compare our tools with existing methods, demonstrating their advantages for visualizing mitochondrial morphology and contrast

SUBMITTER: Valera-Alberni M 

PROVIDER: S-EPMC11391045 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature