FOS mapping reveals two complementary circuits for spatial navigation in mouse.

ABSTRACT: Here, we show that during continuous navigation in a dynamic external environment, mice are capable of developing a foraging strategy based exclusively on changing distal (allothetic) information and that this process may involve two alternative components of the spatial memory circuit: the hippocampus and retrosplenial cortex. To this end, we designed a novel custom apparatus and implemented a behavioral protocol based on the figure-8-maze paradigm with two goal locations associated with distinct contexts. We assessed whether mice are able to learn to retrieve a sequence of rewards guided exclusively by the changing context. We found out that training mice in the apparatus leads to change in strategy from the internal tendency to alternate into navigation based exclusively on visual infor

SUBMITTER: Balcerek E 

PROVIDER: S-EPMC11391074 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature