Exploring the potential mechanism of atrazine-induced dopaminergic neurotoxicity based on integration strategy.

ABSTRACT:

Background

Atrazine (ATR), a commonly used herbicide, is linked to dopaminergic neurotoxicity, which may cause symptoms resembling Parkinson's disease (PD). This study aims to reveal the molecular regulatory networks responsible for ATR exposure and its effects on dopaminergic neurotoxicity based on an integration strategy.

Methods

Our approach involved network toxicology, construction of protein-protein interaction (PPI) networks, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, as well as molecular docking techniques. Subsequently, we validated the predicted results in PC12 cells in vitro.

Results

An integrated analysis strategy indicating that 5 hub targets, including mitogen-activated protein kinase 3 (Mapk3), catalase (Cat)

SUBMITTER: Qi L 

PROVIDER: S-EPMC11391274 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature