Cancer Trial Eligibility and Therapy Modifications for Individuals With Duffy Null-Associated Neutrophil Count.

ABSTRACT:

Importance

Absolute neutrophil counts (ANCs) are used to determine cancer clinical trial (CCT) eligibility and systemic anticancer therapy (SACT) dose modifications. Duffy null-associated ANC (DANC) is a nonpathologic phenotype associated with lower ANC and most frequently seen in individuals with African and Middle Eastern ancestry. It is unclear whether CCTs exclude or SACT regimens modify doses for individuals with ANC within the DANC reference range.

Objective

To investigate CCT exclusions and SACT dose modifications for ANC within the DANC reference range.

Design, setting, and participants

This cross-sectional study of contemporary CCTs and SACT regimens included adult, interventional, phase 3 CCTs for the 5 most prevalent cancers in the US and United Kingdom (pr

SUBMITTER: Hibbs SP 

PROVIDER: S-EPMC11391325 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature