Genome-Derived Ampullary Adenocarcinoma Classifier and Postresection Prognostication.

ABSTRACT:

Importance

Ampullary adenocarcinoma (AA) is characterized by clinical and genomic heterogeneity. A previously developed genomic classifier defined biologically distinct phenotypes with greater accuracy than standard histologic classification. External validation is needed before routine clinical use.

Objective

To test external validity of the prognostic value of the hidden genome classifier of AA.

Design, setting, and participants

This retrospective cohort study took place at 6 international academic institutions. Consecutive patients (n = 192) who underwent curative-intent resection of histologically confirmed AA were included. The data were analyzed from January 2005 through July 2020.

Exposures

The multilevel meta-feature regression model previously trained

SUBMITTER: Ecker BL 

PROVIDER: S-EPMC11391358 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature