Amygdala Reactivity, Antidepressant Discontinuation, and Relapse.

ABSTRACT:

Importance

Antidepressant discontinuation substantially increases the risk of a depression relapse, but the neurobiological mechanisms through which this happens are not known. Amygdala reactivity to negative information is a marker of negative affective processes in depression that is reduced by antidepressant medication, but it is unknown whether amygdala reactivity is sensitive to antidepressant discontinuation or whether any change is related to the risk of relapse after antidepressant discontinuation.

Objective

To investigate whether amygdala reactivity to negative facial emotions changes with antidepressant discontinuation and is associated with subsequent relapse.

Design, setting, and participants

The Antidepressiva Absetzstudie (AIDA) study was a longitudinal,

SUBMITTER: Erdmann T 

PROVIDER: S-EPMC11391364 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature